Gene/Proteome Database (LMPD)
LMPD ID
LMP010757
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
fatty acid beta-oxidation multifunctional protein AIM1
Gene Symbol
Synonyms
ABNORMAL INFLORESCENCE MERISTEM; AIM1; F19B15.40; F19B15_40
Alternate Names
fatty acid beta-oxidation multifunctional protein AIM1
Chromosome
4
EC Number
4.2.1.17
Summary
Functions in beta-oxidation of fatty acids, similar to CuMFP with L-3-hydroxyacyl-CoA hydrolyase , L-3-hydroxyacyl-dehydrogenase, D-3-hydroxyacyl-CoA epimerase, and 3, 2-enoyl-CoA isomerase activities
Orthologs
Proteins
| fatty acid beta-oxidation multifunctional protein AIM1 | |
|---|---|
| Refseq ID | NP_194630 |
| Protein GI | 15235527 |
| UniProt ID | Q9ZPI6 |
| mRNA ID | NM_119045 |
| Length | 721 |
| RefSeq Status | REVIEWED |
| MAKKIGVTMEVGNDGVAVITISNPPVNSLASPIISGLKEKFRDANQRNDVKAIVLIGNNGRFSGGFDINVFQQVHKTGDLSLMPEVSVELVCNLMEDSRKPVVAAVEGLALGGGLELAMACHARVAAPKAQLGLPELTLGVIPGFGGTQRLPRLVGLAKATDMILLSKSISSEEGHKLGLIDALVPPGDVLSTSRKWALDIAEGRKPFLQSLHRTDKIGSLSEARAILKNSRQLAKKIAPNMPQHHACIEVIEEGIIHGGYSGVLKEAEVFKQLVLSDTAKGLVHVFFAQRATSKVPNVTDVGLKPRPIKKVAVIGGGLMGSGIATALLLSNIRVVLKEINSEFLMKGIKSVEANMKSLVSRGKLTQDKAGKALSLFKGVLDYTEFNDVDMVIEAVIENIQLKQNIFKEIEKVCSPHCILASNTSTIDLDVIGEKTNSKDRIVGAHFFSPAHLMPLLEIVRSKNTSAQVILDLMAVGKAIKKVPVVVGNCIGFAVNRTFFPYSQAAHMLANLGVDLFRIDSVITSFGLPLGPFQLGDLAGHGIGLAVGPIYAKVYGDRMFRSPMTELLLKSGRNGKINGRGYYIYEKGSKPKPDPSVLSIVEKSRKLTNIMPGGKPISVTDKEIVEMILFPVVNEACRVLDEGVVIRASDLDIASVLGMSFPSYRGGIVFWADTVGPKYIYERLKKLSETYGSFFKPSRYLEERAMNGMLLSESKSSRSKL | |
Gene Information
Entrez Gene ID
Gene Name
fatty acid beta-oxidation multifunctional protein AIM1
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005618 | IDA:TAIR | C | cell wall |
| GO:0009507 | IDA:TAIR | C | chloroplast |
| GO:0005777 | IDA:TAIR | C | peroxisome |
| GO:0009506 | IDA:TAIR | C | plasmodesma |
| GO:0003857 | IDA:UniProtKB | F | 3-hydroxyacyl-CoA dehydrogenase activity |
| GO:0008692 | IEA:UniProtKB-EC | F | 3-hydroxybutyryl-CoA epimerase activity |
| GO:0050662 | IEA:InterPro | F | coenzyme binding |
| GO:0004165 | IEA:UniProtKB-EC | F | dodecenoyl-CoA delta-isomerase activity |
| GO:0004300 | IDA:UniProtKB | F | enoyl-CoA hydratase activity |
| GO:0006635 | ISS:TAIR | P | fatty acid beta-oxidation |
| GO:0009908 | IMP:TAIR | P | flower development |
| GO:0009695 | IMP:UniProtKB | P | jasmonic acid biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ath00071 | Fatty acid degradation |
| ath_M00113 | Jasmonic acid biosynthesis |
| ath00592 | alpha-Linolenic acid metabolism |
| ath_M00087 | beta-Oxidation |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR006108 | 3-hydroxyacyl-CoA dehydrogenase, C-terminal |
| IPR006176 | 3-hydroxyacyl-CoA dehydrogenase, NAD binding |
| IPR006180 | 3-hydroxyacyl-CoA dehydrogenase, conserved site |
| IPR008927 | 6-phosphogluconate dehydrogenase, C-terminal-like |
| IPR029045 | ClpP/crotonase-like domain |
| IPR001753 | Crotonase_core_superfam |
| IPR013328 | Dehydrogenase, multihelical |
| IPR018376 | Enoyl-CoA hydratase/isomerase, conserved site |
| IPR016040 | NAD(P)-binding domain |
UniProt Annotations
Entry Information
Gene Name
fatty acid beta-oxidation multifunctional protein AIM1
Protein Entry
AIM1_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Biophysicochemical Properties | Kinetic parameters: KM=115 uM for crotonyl-CoA {ECO:0000269|PubMed:10521521}; |
| Catalytic Activity | (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl- CoA + H(2)O. |
| Catalytic Activity | (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl- CoA. |
| Catalytic Activity | (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. |
| Catalytic Activity | (S)-3-hydroxybutanoyl-CoA = (R)-3- hydroxybutanoyl-CoA. |
| Disruption Phenotype | Reduced rosette size, twisted leaves, and abnormal and sterile flowers. {ECO:0000269|PubMed:10521521}. |
| Domain | The epimerase and isomerase activities are contained in the N-terminal region while the dehydrogenase activity is in the C-terminal region. {ECO:0000250}. |
| Function | Involved in peroxisomal fatty acid beta-oxidation. Required for wound-induced jasmonate biosynthesis. Possesses enoyl-CoA hydratase activity against short chain substrates (C4- C6) and 3-hydroxyacyl-CoA dehydrogenase activity against chains of variable sizes (C6-C16). {ECO:0000269|PubMed:10521521, ECO:0000269|PubMed:17544464, ECO:0000269|PubMed:20463021}. |
| Pathway | Lipid metabolism; fatty acid beta-oxidation. |
| Similarity | In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}. |
| Similarity | In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family. {ECO:0000305}. |
| Subcellular Location | Peroxisome {ECO:0000305}. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10521521}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010757 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 15235527 | RefSeq | NP_194630 | 721 | fatty acid beta-oxidation multifunctional protein AIM1 |
Identical Sequences to LMP010757 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15235527 | EMBL | CBG04539.1 | 721 | unnamed protein product [Arabidopsis thaliana] |
| GI:15235527 | EMBL | CBV18061.1 | 721 | unnamed protein product [Arabidopsis thaliana] |
| GI:15235527 | GenBank | ACW85526.1 | 721 | Sequence 1519 from patent US 7569389 |
| GI:15235527 | GenBank | AEE85572.1 | 721 | fatty acid beta-oxidation multifunctional protein AIM1 [Arabidopsis thaliana] |
| GI:15235527 | GenBank | AGX95946.1 | 721 | Sequence 72152 from patent US 8541208 |
| GI:15235527 | SwissProt | Q9ZPI6.1 | 721 | RecName: Full=Peroxisomal fatty acid beta-oxidation multifunctional protein AIM1; AltName: Full=Protein ABNORMAL INFLORESCENCE MERISTEM 1; Short=AtAIM1; Includes: RecName: Full=Enoyl-CoA hydratase/3-2-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase; Includes: RecName: Full=3-hydroxyacyl-CoA dehydrogenase [Arabidopsis thaliana] |
Related Sequences to LMP010757 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15235527 | GenBank | ACW85527.1 | 713 | Sequence 1520 from patent US 7569389 |
| GI:15235527 | GenBank | EFH43687.1 | 721 | hypothetical protein ARALYDRAFT_491857 [Arabidopsis lyrata subsp. lyrata] |
| GI:15235527 | RefSeq | XP_002867428.1 | 721 | hypothetical protein ARALYDRAFT_491857 [Arabidopsis lyrata subsp. lyrata] |
| GI:15235527 | RefSeq | XP_010433148.1 | 721 | PREDICTED: peroxisomal fatty acid beta-oxidation multifunctional protein AIM1 [Camelina sativa] |
| GI:15235527 | RefSeq | XP_010438362.1 | 721 | PREDICTED: peroxisomal fatty acid beta-oxidation multifunctional protein AIM1-like [Camelina sativa] |
| GI:15235527 | RefSeq | XP_010447902.1 | 721 | PREDICTED: peroxisomal fatty acid beta-oxidation multifunctional protein AIM1-like [Camelina sativa] |