Gene/Proteome Database (LMPD)
LMPD ID
LMP010876
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phospholipase D gamma 1
Gene Symbol
Synonyms
maternal effect embryo arrest 54; MEE54; phospholipase D gamma 1; PLDGAMMA1
Alternate Names
phospholipase D gamma 1
Chromosome
4
EC Number
3.1.4.4
Summary
phospholipase D (gamma)
Orthologs
Proteins
| phospholipase D gamma 1 | |
|---|---|
| Refseq ID | NP_192922 |
| Protein GI | 15234335 |
| UniProt ID | Q9T053 |
| mRNA ID | NM_117255 |
| Length | 858 |
| RefSeq Status | REVIEWED |
| MAYHPAYTETMSMGGGSSHGGGQQYVPFATSSGSLRVELLHGNLDIWVKEAKHLPNMDGFHNRLGGMLSGLGRKKVEGEKSSKITSDPYVTVSISGAVIGRTFVISNSENPVWMQHFDVPVAHSAAEVHFVVKDSDIIGSQIMGAVGIPTEQLCSGNRIEGLFPILNSSGKPCKQGAVLGLSIQYTPMERMRLYQMGVGSGNECVGVPGTYFPLRKGGRVTLYQDAHVDDGTLPSVHLDGGIQYRHGKCWEDMADAIRQARRLIYITGWSVFHPVRLVRRTNDPTEGTLGELLKVKSQEGVRVLVLVWDDPTSRSLLGFKTQGVMNTSDEETRRFFKHSSVQVLLCPRSGGKGHSFIKKSEVGTIYTHHQKTVIVDAEAAQNRRKIVAFVGGLDLCNGRFDTPKHPLFRTLKTLHKDDFHNPNFVTTADDGPREPWHDLHSKIDGPAAYDVLANFEERWMKASKPRGIGKLKSSSDDSLLRIDRIPDIVGLSEASSANDNDPESWHVQVFRSIDSSSVKGFPKDPKEATGRNLLCGKNILIDMSIHAAYVKAIRSAQHFIYIENQYFLGSSFNWDSNKDLGANNLIPMEIALKIANKIRAREKFAAYIVIPMWPEGAPTSNPIQRILYWQHKTMQMMYQTIYKALVEVGLDSQFEPQDFLNFFCLGTREVPVGTVSVYNSPRKPPQPNANANAAQVQALKSRRFMIYVHSKGMVVDDEFVLIGSANINQRSLEGTRDTEIAMGGYQPHYSWAMKGSRPHGQIFGYRMSLWAEHLGFLEQGFEEPENMECVRRVRQLSELNWRQYAAEEVTEMSGHLLKYPVQVDRTGKVSSLPGCETFPDLGGKIIGSFLALQENLTI | |
Gene Information
Entrez Gene ID
Gene Name
phospholipase D gamma 1
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
| GO:0005886 | IDA:TAIR | C | plasma membrane |
| GO:0070290 | IEA:UniProtKB-EC | F | N-acylphosphatidylethanolamine-specific phospholipase D activity |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0005546 | IDA:TAIR | F | phosphatidylinositol-4,5-bisphosphate binding |
| GO:0004630 | IDA:TAIR | F | phospholipase D activity |
| GO:0009816 | IGI:TAIR | P | defense response to bacterium, incompatible interaction |
| GO:0009793 | IMP:TAIR | P | embryo development ending in seed dormancy |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0006643 | IMP:TAIR | P | membrane lipid metabolic process |
| GO:0046470 | IEA:InterPro | P | phosphatidylcholine metabolic process |
| GO:0010044 | IMP:TAIR | P | response to aluminum ion |
| GO:0006979 | IMP:TAIR | P | response to oxidative stress |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ath04144 | Endocytosis |
| ath00565 | Ether lipid metabolism |
| ath00564 | Glycerophospholipid metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 6254320 | Synthesis of PG |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | A phosphatidylcholine + H(2)O = choline + a phosphatidate. |
| Caution | It is uncertain whether Met-1 or Met-11 is the initiator. {ECO:0000305}. |
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Ca(2+). Requires micromolar level (PIP2-dependent).; |
| Domain | C2 domain is a calcium-binding fold, and the binding promotes the protein association with membranes. In PLD gamma, all the calcium-coordinating acidic amino acids are conserved. |
| Enzyme Regulation | Inhibited by neomycin. |
| Function | Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond. Plays an important role in various cellular processes, including phytohormone action, vesicular trafficking, secretion, cytoskeletal arrangement, meiosis, tumor promotion, pathogenesis, membrane deterioration and senescence. Can use phosphatidylserine but prefers ethanolamine-containing lipids as substrates. |
| Induction | Activated by wounding, heavy metal, methyl salicylate, osmotic and salt stresses. |
| Sequence Caution | Sequence=AAB87672.1; Type=Frameshift; Positions=60, 79, 260, 300, 465, 758; Evidence={ECO:0000305}; |
| Similarity | Belongs to the phospholipase D family. C2-PLD subfamily. {ECO:0000305}. |
| Similarity | Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}. |
| Similarity | Contains 2 PLD phosphodiesterase domains. {ECO:0000255|PROSITE-ProRule:PRU00153}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10198096}. Membrane {ECO:0000269|PubMed:10198096}; Peripheral membrane protein {ECO:0000269|PubMed:10198096}. Note=Found mainly associated with intracellular membranes but also with mitochondrial membranes, nuclei and clathrin-coated vesicles. Not found in chloroplast. |
| Tissue Specificity | Highly expressed in roots and flowers, moderately in stems, leaves and seedlings and low in siliques. Not detected in seeds. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010876 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 15234335 | RefSeq | NP_192922 | 858 | phospholipase D gamma 1 |
Identical Sequences to LMP010876 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15234335 | EMBL | CAB44323.1 | 858 | putative phospholipase D-gamma [Arabidopsis thaliana] |
| GI:15234335 | EMBL | CAB78228.1 | 858 | putative phospholipase D-gamma [Arabidopsis thaliana] |
| GI:15234335 | GenBank | AAM20421.1 | 858 | putative phospholipase D-gamma [Arabidopsis thaliana] |
| GI:15234335 | GenBank | AAN72151.1 | 858 | putative phospholipase D-gamma [Arabidopsis thaliana] |
| GI:15234335 | GenBank | AEE83058.1 | 858 | phospholipase D gamma 1 [Arabidopsis thaliana] |
| GI:15234335 | SwissProt | Q9T053.1 | 858 | RecName: Full=Phospholipase D gamma 1; Short=AtPLDgamma1; Short=PLD gamma 1; AltName: Full=Choline phosphatase; AltName: Full=Lecithinase D; AltName: Full=Lipophosphodiesterase II [Arabidopsis thaliana] |
Related Sequences to LMP010876 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15234335 | GenBank | EFH50986.1 | 861 | PLDGAMMA1 [Arabidopsis lyrata subsp. lyrata] |
| GI:15234335 | GenBank | EFH50987.1 | 859 | PLDGAMMA1 [Arabidopsis lyrata subsp. lyrata] |
| GI:15234335 | RefSeq | XP_002874727.1 | 861 | PLDGAMMA1 [Arabidopsis lyrata subsp. lyrata] |
| GI:15234335 | RefSeq | XP_010434095.1 | 861 | PREDICTED: phospholipase D gamma 1 [Camelina sativa] |
| GI:15234335 | RefSeq | XP_010422137.1 | 861 | PREDICTED: phospholipase D gamma 1-like [Camelina sativa] |
| GI:15234335 | RefSeq | XP_010455598.1 | 861 | PREDICTED: phospholipase D gamma 1-like [Camelina sativa] |