Gene/Proteome Database (LMPD)

LMPD ID
LMP011291
Gene ID
818028
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
geranyl diphosphate synthase 1
Gene Symbol
GPS1
Synonyms
geranyl diphosphate synthase 1; GERANYLPYROPHOSPHATE SYNTHASE; GPPS; GPS1; T31E10.3; T31E10_3
Alternate Names
geranyl diphosphate synthase 1
Chromosome
2
EC Number
2.5.1.85
Summary
Encodes a geranyl diphosphate synthase. RNAi lines are dwarf. T-DNA knock-out lines are embryo lethal.
Orthologs
View orthologs and multiple alignments for GPS1

Proteins

geranyl diphosphate synthase 1
Refseq ID NP_001031483
Protein GI 79324330
UniProt ID Q5HZ00
mRNA ID NM_001036406
Length 422
RefSeq Status REVIEWED
MLFTRSVARISSKFLRNRSFYGSSQSLASHRFAIIPDQGHSCSDSPHKGYVCRTTYSLKSPVFGGFSHQLYHQSSSLVEEELDPFSLVADELSLLSNKLREMVLAEVPKLASAAEYFFKRGVQGKQFRSTILLLMATALNVRVPEALIGESTDIVTSELRVRQRGIAEITEMIHVASLLHDDVLDDADTRRGVGSLNVVMGNKMSVLAGDFLLSRACGALAALKNTEVVALLATAVEHLVTGETMEITSSTEQRYSMDYYMQKTYYKTASLISNSCKAVAVLTGQTAEVAVLAFEYGRNLGLAFQLIDDILDFTGTSASLGKGSLSDIRHGVITAPILFAMEEFPQLREVVDQVEKDPRNVDIALEYLGKSKGIQRARELAMEHANLAAAAIGSLPETDNEDVKRSRRALIDLTHRVITRNK
geranyl diphosphate synthase 1
Refseq ID NP_850234
Protein GI 30686146
UniProt ID Q5HZ00
mRNA ID NM_179903
Length 321
RefSeq Status REVIEWED
MVLAEVPKLASAAEYFFKRGVQGKQFRSTILLLMATALNVRVPEALIGESTDIVTSELRVRQRGIAEITEMIHVASLLHDDVLDDADTRRGVGSLNVVMGNKMSVLAGDFLLSRACGALAALKNTEVVALLATAVEHLVTGETMEITSSTEQRYSMDYYMQKTYYKTASLISNSCKAVAVLTGQTAEVAVLAFEYGRNLGLAFQLIDDILDFTGTSASLGKGSLSDIRHGVITAPILFAMEEFPQLREVVDQVEKDPRNVDIALEYLGKSKGIQRARELAMEHANLAAAAIGSLPETDNEDVKRSRRALIDLTHRVITRNK

Gene Information

Entrez Gene ID
818028
Gene Name
geranyl diphosphate synthase 1
Gene Symbol
GPS1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009507 IDA:TAIR C chloroplast
GO:0005739 IDA:TAIR C mitochondrion
GO:0009536 IDA:TAIR C plastid
GO:0052924 IEA:UniProtKB-EC F all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004659 IDA:TAIR F prenyltransferase activity
GO:0050347 IMP:TAIR F trans-octaprenyltranstransferase activity
GO:0009793 IMP:TAIR P embryo development ending in seed dormancy
GO:0008299 IEA:UniProtKB-KW P isoprenoid biosynthetic process
GO:0006744 IMP:TAIR P ubiquinone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath01100 Metabolic pathways
ath00900 Terpenoid backbone biosynthesis
ko00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR008949 Isoprenoid synthase domain
IPR000092 Polyprenyl synthetase
IPR017446 Polyprenyl synthetase-related

UniProt Annotations

Entry Information

Gene Name
geranyl diphosphate synthase 1
Protein Entry
SPS3_ARATH
UniProt ID
Q5HZ00
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5HZ00-1; Sequence=Displayed; Name=2; IsoId=Q5HZ00-2; Sequence=VSP_042136; Note=No experimental confirmation available.; Name=3; IsoId=Q5HZ00-3; Sequence=VSP_042135; Note=Derived from EST data. No experimental confirmation available.;
Catalytic Activity Geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate. {ECO:0000269|PubMed:21220764}.
Caution Was proposed to be a geranyl diphosphate synthase involved in gibberellins biosynthesis. {ECO:0000305|PubMed:11069698}.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000250};
Disruption Phenotype Embryo lethal. {ECO:0000269|PubMed:17877699, ECO:0000269|PubMed:21950843}.
Function May be involved in the supply of solanesyl diphosphate for ubiquinone-9 biosynthesis in mitochondria. Synthesizes C25 to C45 medium / long-chain products depending on the type of substrate available. Can use geranyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrates, but not dimethylallyl diphosphate. {ECO:0000269|PubMed:11069698, ECO:0000269|PubMed:17877699, ECO:0000269|PubMed:21220764, ECO:0000269|PubMed:21950843}.
Miscellaneous Silencing of At2g34630 decreases ubiquinone-9 biosynthesis in mitochondria but has no effect on plastoquinone-9 biosynthesis in chloroplast, maybe due to the redundancy with At1g17050.
Sequence Caution Sequence=AAC26705.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the FPP/GGPP synthase family. {ECO:0000305}.
Subcellular Location Plastid, chloroplast. Mitochondrion.
Subunit Homodimer. {ECO:0000269|PubMed:21220764}.
Tissue Specificity Ubiquitous. Highest expression in seeds and shoot apical meristem. {ECO:0000269|PubMed:21950843}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011291 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
79324330 RefSeq NP_001031483 422 geranyl diphosphate synthase 1
30686146 RefSeq NP_850234 321 geranyl diphosphate synthase 1

Identical Sequences to LMP011291 proteins

Reference Database Accession Length Protein Name
GI:79324330 GenBank AAW39025.1 422 At2g34630 [Arabidopsis thaliana]
GI:30686146 GenBank AAY07937.1 321 Sequence 12 from patent US 6872815
GI:30686146 GenBank ABL57921.1 321 Sequence 12 from patent US 7141718
GI:30686146 GenBank ABW49203.1 321 Sequence 12 from patent US 7265207
GI:30686146 GenBank ACJ98850.1 321 Sequence 12 from patent US 7420101
GI:30686146 GenBank AEC09000.1 321 geranyl diphosphate synthase 1 [Arabidopsis thaliana]
GI:79324330 GenBank AEC09001.1 422 geranyl diphosphate synthase 1 [Arabidopsis thaliana]
GI:79324330 GenBank AFX58112.1 422 Sequence 36 from patent US 8309323
GI:30686146 GenBank AGF06982.1 321 Sequence 12 from patent US 8362324
GI:79324330 SwissProt Q5HZ00.1 422 RecName: Full=Solanesyl diphosphate synthase 3, chloroplastic/mitochondrial; AltName: Full=All-trans-nonaprenyl-diphosphate synthase 3 (geranylgeranyl-diphosphate specific); AltName: Full=Geranyl diphosphate synthase 1; AltName: Full=Trans-type polyprenyl pyrophosphate synthase; Short=AtPPPS; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP011291 proteins

Reference Database Accession Length Protein Name
GI:79324330 EMBL CAC16849.1 422 geranyl diphosphate synthase [Arabidopsis thaliana]
GI:79324330 EMBL CAG24431.1 422 unnamed protein product [Arabidopsis thaliana]
GI:79324330 EMBL CAG24437.1 422 unnamed protein product [Arabidopsis thaliana]
GI:79324330 EMBL CAI70057.1 422 unnamed protein product [Arabidopsis thaliana]
GI:79324330 EMBL CAI72044.1 422 unnamed protein product [Arabidopsis thaliana]
GI:30686146 GenBank AAM13005.1 423 putative trans-prenyltransferase [Arabidopsis thaliana]
GI:30686146 GenBank AAW39025.1 422 At2g34630 [Arabidopsis thaliana]
GI:79324330 GenBank ACE50420.1 422 Sequence 122 from patent US 7381541
GI:30686146 GenBank AEC09001.1 422 geranyl diphosphate synthase 1 [Arabidopsis thaliana]
GI:30686146 GenBank AFX58112.1 422 Sequence 36 from patent US 8309323
GI:30686146 RefSeq NP_001031483.1 422 geranyl diphosphate synthase 1 [Arabidopsis thaliana]
GI:30686146 SwissProt Q5HZ00.1 422 RecName: Full=Solanesyl diphosphate synthase 3, chloroplastic/mitochondrial; AltName: Full=All-trans-nonaprenyl-diphosphate synthase 3 (geranylgeranyl-diphosphate specific); AltName: Full=Geranyl diphosphate synthase 1; AltName: Full=Trans-type polyprenyl pyrophosphate synthase; Short=AtPPPS; Flags: Precursor [Arabidopsis thaliana]