Gene/Proteome Database (LMPD)

LMPD ID
LMP011446
Gene ID
819647
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
zeta-carotene desaturase
Gene Symbol
ZDS
Synonyms
PDE181; PIGMENT DEFECTIVE EMBRYO 181; PRE ZETA-CAROTENE DESATURASE PRECURSOR; SPC1; SPONTANEOUS CELL DEATH 1; T9J14.18; ZDS; zeta-carotene desaturase
Alternate Names
zeta-carotene desaturase
Chromosome
3
EC Number
1.3.5.6
Summary
Involved in the biosynthesis of carotenes and xanthophylls, reduces zeta-carotene to lycopene.
Orthologs
View orthologs and multiple alignments for ZDS

Proteins

zeta-carotene desaturase
Refseq ID NP_187138
Protein GI 15229367
UniProt ID Q38893
mRNA ID NM_111359
Length 558
RefSeq Status REVIEWED
MASSVVFAATGSLSVPPLKSRRFYVNSSLDSDVSDMSVNAPKGLFPPEPVPYKGPKLKVAIIGAGLAGMSTAVELLDQGHEVDIYDSRTFIGGKVGSFVDRRGNHIEMGLHVFFGCYNNLFRLMKKVGAEKNLLVKDHTHTFINKDGTIGELDFRFPVGAPIHGIRAFLVTNQLKPYDKLRNSLALALSPVVKALVDPDGAMRDIRNLDSISFSDWFLSKGGTRASIQRMWDPVAYALGFIDCDNMSARCMLTIFSLFATKTEASLLRMLKGSPDVYLSGPIKQYITDRGGRIHLRWGCREILYDKSADGETYVTGLAISKATNKKIVKADVYVAACDVPGIKRLLPKEWRESRFFNDIYELEGVPVVTVQLRYNGWVTELQDIELARQLKRAVGLDNLLYTPDADFSCFADLALASPADYYIEGQGTLLQCVLTPGDPYMRMPNDKIIEKVAMQVTELFPSSRGLEVTWSSVVKIAQSLYREAPGKDPFRPDQKTPIKNFFLAGSYTKQDYIDSMEGATLSGRQASSYICDAGEELAELNKKLSSSATAVPDELSLV
zeta-carotene desaturase
Refseq ID NP_974222
Protein GI 42572255
UniProt ID Q38893
mRNA ID NM_202493
Length 558
RefSeq Status REVIEWED
Protein sequence is identical to GI:15229367 (mRNA isoform)

Gene Information

Entrez Gene ID
819647
Gene Name
zeta-carotene desaturase
Gene Symbol
ZDS
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009507 IDA:TAIR C chloroplast
GO:0009941 IDA:TAIR C chloroplast envelope
GO:0009509 IEA:UniProtKB-KW C chromoplast
GO:0052887 IEA:UniProtKB-EC F 7,9,9'-tricis-neurosporene:quinone oxidoreductase activity
GO:0052886 IEA:UniProtKB-EC F 9,9'-dicis-carotene:quinone oxidoreductase activity
GO:0016719 IEA:InterPro F carotene 7,8-desaturase activity
GO:0052889 IEA:UniProtKB-EC P 9,9'-di-cis-zeta-carotene desaturation to 7,9,7',9'-tetra-cis-lycopene
GO:0016117 IEA:UniProtKB-KW P carotenoid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath00906 Carotenoid biosynthesis
ath01100 Metabolic pathways
ath_M00097 beta-Carotene biosynthesis, GGAP => beta-carotene

Domain Information

InterPro Annotations

Accession Description
IPR002937 Amine oxidase
IPR016040 NAD(P)-binding domain
IPR014103 Zeta-carotene desaturase

UniProt Annotations

Entry Information

Gene Name
zeta-carotene desaturase
Protein Entry
ZDS_ARATH
UniProt ID
Q38893
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity 9,9'-di-cis-zeta-carotene + 2 quinone = 7,9,7',9'-tetra-cis-lycopene + 2 quinol. {ECO:0000269|PubMed:9914519}.
Cofactor Name=decylplastoquinone; Xref=ChEBI:CHEBI:72953; Evidence={ECO:0000250}; Name=6-decylubiquinone; Xref=ChEBI:CHEBI:52020; Evidence={ECO:0000250}; Note=Lipophilic quinones such as decyl-plastoquinone or decyl- ubiquinone. {ECO:0000250};
Function Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'. Shows stereoselectivity toward trans C15- C15'zeta-carotene double bond. The zeta-carotene produced by the phytoene desaturase PDS has a C15-C15' double bond in the cis configuration and it requires isomerization before being recognized as substrate by ZDS. The main product is 7,9,7',9'- tetra-cis-lycopene (pro-lycopene). {ECO:0000269|PubMed:9914519}.
Pathway Carotenoid biosynthesis; lycopene biosynthesis.
Similarity Belongs to the zeta carotene desaturase family. {ECO:0000305}.
Subcellular Location Plastid, chloroplast. Plastid, chromoplast.

Identical and Related Proteins

Unique RefSeq proteins for LMP011446 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15229367 RefSeq NP_187138 558 zeta-carotene desaturase

Identical Sequences to LMP011446 proteins

Reference Database Accession Length Protein Name
GI:15229367 GenBank AEE74148.1 558 zeta-carotene desaturase [Arabidopsis thaliana]
GI:15229367 GenBank AEE74149.1 558 zeta-carotene desaturase [Arabidopsis thaliana]
GI:15229367 GenBank AFX28697.1 558 Sequence 9757 from patent US 8299318
GI:15229367 GenBank AFX49323.1 558 Sequence 51156 from patent US 8299318
GI:15229367 GenBank AGF14159.1 558 Sequence 13578 from patent US 8362325
GI:15229367 SwissProt Q38893.3 558 RecName: Full=Zeta-carotene desaturase, chloroplastic/chromoplastic; AltName: Full=9,9'-di-cis-zeta-carotene desaturase; AltName: Full=Carotene 7,8-desaturase; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP011446 proteins

Reference Database Accession Length Protein Name
GI:15229367 GenBank AAA91161.1 558 zeta-carotene desaturase precursor [Arabidopsis thaliana]
GI:15229367 GenBank AAF85796.1 558 zeta-carotene desaturase precursor [Arabidopsis thaliana]
GI:15229367 GenBank AAM63349.1 558 putative zeta-carotene desaturase precursor [Arabidopsis thaliana]
GI:15229367 GenBank EFH58637.1 561 zeta-carotene desaturase precursor [Arabidopsis lyrata subsp. lyrata]
GI:15229367 RefSeq XP_002882378.1 561 zeta-carotene desaturase precursor [Arabidopsis lyrata subsp. lyrata]
GI:15229367 RefSeq XP_006297343.1 561 hypothetical protein CARUB_v10013363mg [Capsella rubella]