Gene/Proteome Database (LMPD)

LMPD ID
LMP011471
Gene ID
30355
Species
Danio rerio (Zebrafish)
Gene Name
apolipoprotein A-Ia
Gene Symbol
apoa1a
Synonyms
apoa; cb49; apoa1; wu:fb33f01; zgc:103718
Alternate Names
apolipoprotein A-I; apo-AI; apoA-I; etID32161.5; etID309895.5; apolipoprotein A1
Chromosome
5

Proteins

apolipoprotein A-I precursor
Refseq ID NP_571203
Protein GI 18858281
UniProt ID O42363
mRNA ID NM_131128
Length 262
RefSeq Status PROVISIONAL
MKFVALALTLLLALGSQANLFQADAPTQLEHYKAAALVYLNQVKDQAEKALDNLDGTDYEQYKLQLSESLTKLQEYAQTTSQALTPYAETISTQLMENTKQLRERVMTDVEDLRSKLEPHRAELYTALQKHIDEYREKLEPVFQEYSALNRQNAEQLRAKLEPLMDDIRKAFESNIEETKSKVVPMVEAVRTKLTERLEDLRTMAAPYAEEYKEQLVKAVEEAREKIAPHTQDLQTRMEPYMENVRTTFAQMYETIAKAIQA

Gene Information

Entrez Gene ID
30355
Gene Name
apolipoprotein A-Ia
Gene Symbol
apoa1a
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IDA:ZFIN C extracellular region
GO:0034364 IEA:UniProtKB-KW C high-density lipoprotein particle
GO:0008289 IEA:InterPro F lipid binding
GO:0008203 IEA:UniProtKB-KW P cholesterol metabolic process
GO:0006869 IEA:UniProtKB-KW P lipid transport
GO:0042157 IEA:InterPro P lipoprotein metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
dre03320 PPAR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
6176889 Scavenging by Class A Receptors
6176890 Scavenging by Class B Receptors
6176885 Scavenging of heme from plasma

Domain Information

InterPro Annotations

Accession Description
IPR000074 Apolipoprotein A/E

UniProt Annotations

Entry Information

Gene Name
apolipoprotein A-Ia
Protein Entry
APOA1_DANRE
UniProt ID
O42363
Species
Zebrafish

Comments

Comment Type Description
Developmental Stage Highly expressed in the yolk syncytial layer during embryonic (starting at the gastrula stage) and early larval development, an extraembryonic structure implicated in embryonic and larval nutrition. {ECO:0000269|PubMed:9238027}.
Function Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). {ECO:0000250}.
Sequence Caution Sequence=AAH83473.1; Type=Frameshift; Positions=24; Evidence={ECO:0000305};
Similarity Belongs to the apolipoprotein A1/A4/E family. {ECO:0000305}.
Subcellular Location Secreted.

Identical and Related Proteins

Unique RefSeq proteins for LMP011471 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18858281 RefSeq NP_571203 262 apolipoprotein A-I precursor

Identical Sequences to LMP011471 proteins

Reference Database Accession Length Protein Name
GI:18858281 EMBL CAA74004.1 262 apolipoprotein A-I precursor protein [Danio rerio]
GI:18858281 GenBank AAY74293.1 262 Sequence 31 from patent US 6897039
GI:18858281 SwissProt O42363.1 262 RecName: Full=Apolipoprotein A-I; Short=Apo-AI; Short=ApoA-I; AltName: Full=Apolipoprotein A1; Contains: RecName: Full=Proapolipoprotein A-I; Short=ProapoA-I; Flags: Precursor [Danio rerio]

Related Sequences to LMP011471 proteins

Reference Database Accession Length Protein Name
GI:18858281 GenBank AAH83473.1 167 Apoa protein [Danio rerio]
GI:18858281 GenBank ACI15890.1 262 apolipoprotein-A-I-2 [Hemibarbus mylodon]
GI:18858281 GenBank ADO28591.1 258 apolipoprotein A-I [Ictalurus punctatus]
GI:18858281 GenBank AGT95863.1 258 apolipoprotein A-I [Ictalurus punctatus]
GI:18858281 RefSeq NP_001187398.1 258 apolipoprotein A-I precursor [Ictalurus punctatus]
GI:18858281 RefSeq XP_007261056.1 254 PREDICTED: apolipoprotein A-I-like [Astyanax mexicanus]