Gene/Proteome Database (LMPD)
Proteins
lysophospholipid acyltransferase 2 | |
---|---|
Refseq ID | NP_620154 |
Protein GI | 40548387 |
UniProt ID | Q6ZWT7 |
mRNA ID | NM_138799 |
Length | 520 |
MATTSTTGSTLLQPLSNAVQLPIDQVNFVVCQLFALLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFMGILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFKMFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKKFDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ |
Gene Information
Entrez Gene ID
Gene Name
membrane bound O-acyltransferase domain containing 2
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005789 | TAS:Reactome | C | endoplasmic reticulum membrane |
GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
GO:0003841 | IEA:UniProtKB-EC | F | 1-acylglycerol-3-phosphate O-acyltransferase activity |
GO:0046474 | TAS:Reactome | P | glycerophospholipid biosynthetic process |
GO:0036151 | TAS:Reactome | P | phosphatidylcholine acyl-chain remodeling |
GO:0036152 | TAS:Reactome | P | phosphatidylethanolamine acyl-chain remodeling |
GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
KEGG Pathway ID | Description |
---|---|
hsa00561 | Glycerolipid metabolism |
ko00561 | Glycerolipid metabolism |
hsa00564 | Glycerophospholipid metabolism |
ko00564 | Glycerophospholipid metabolism |
hsa01100 | Metabolic pathways |
M00089 | Triacylglycerol biosynthesis |
BIOCYC Pathway Links
BIOCYC Pathway ID | Description |
---|---|
PWY-5667 | CDP-diacylglycerol biosynthesis I |
PWY4FS-8 | phosphatidylglycerol biosynthesis II (non-plastidic) |
TRIGLSYN-PWY | triacylglycerol biosynthesis |
REACTOME Pathway Links
REACTOME Pathway ID | Description |
---|---|
REACT_120829 | Acyl chain remodelling of PC |
REACT_121369 | Acyl chain remodelling of PE |
REACT_121401 | Glycerophospholipid biosynthesis |
REACT_111217 | Metabolism |
REACT_22258 | Metabolism of lipids and lipoproteins |
REACT_120870 | Phospholipid metabolism |
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR004299 | Membrane bound O-acyl transferase, MBOAT |
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycero-3- phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3- phosphoethanolamine. |
Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. |
Enzyme Regulation | Partially inhibited by thimerosal. |
Function | Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2- diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle |
Pathway | Lipid metabolism; phospholipid metabolism. |
Sequence Caution | Sequence=BAC11204.1; Type=Erroneous initiation; Evidence= ; |
Similarity | Belongs to the membrane-bound acyltransferase family |
Subcellular Location | Membrane ; Multi-pass membrane protein |
Tissue Specificity | Expressed in neutrophils |
Identical and Related Proteins
Unique RefSeq proteins for LMP012365 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
40548387 | RefSeq | NP_620154 | 520 | lysophospholipid acyltransferase 2 |
Identical Sequences to LMP012365 proteins
Reference | Database | Accession | Length | Protein Name |
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Related Sequences to LMP012365 proteins
Reference | Database | Accession | Length | Protein Name |
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