Gene/Proteome Database (LMPD)

LMPD ID
LMP012440
Gene ID
24816
Species
Rattus norvegicus (Rat)
Gene Name
thromboxane A2 receptor
Gene Symbol
Tbxa2r
Alternate Names
thromboxane A2 receptor; TXR2; TXA2-R; Thromboxane receptor; prostanoid TP receptor;
Chromosome
7
Map Location
7q11
Summary
binds thromboxane and induces an increase in cytosolic Ca2+ levels; may play a role renal electrolyte metabolism; may mediate vascular smooth muscle cell contraction and proliferation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Tbxa2r

Proteins

thromboxane A2 receptor
Refseq ID NP_058750
Protein GI 8394422
UniProt ID P34978
mRNA ID NM_017054
Length 341
MWLNSTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAVVASQHAALLDWRATDPGCRLCHFMGAAMVFFGLCPLLLGAAMAAERFVGITRPFSRPAATSRRAWATVGLVWVGAGTLGLLPLLGLGRYSVQYPGSWCFLTLGAGRGDVAFGLMFALLGSVSVGLSLLLNTVSVATLCRVYHAREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFILQTLLQTLPVMSPSGQLLRTTERQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFTSQLQAVSLHSPPTQAMLSGP

Gene Information

Entrez Gene ID
24816
Gene Name
thromboxane A2 receptor
Gene Symbol
Tbxa2r
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0001669 IDA:RGD C acrosomal vesicle
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004960 IDA:RGD F thromboxane receptor activity
GO:0006954 IEA:Ensembl P inflammatory response
GO:0045766 IDA:RGD P positive regulation of angiogenesis
GO:0045777 IMP:RGD P positive regulation of blood pressure
GO:0007204 IDA:RGD P positive regulation of cytosolic calcium ion concentration
GO:0045987 IEA:Ensembl P positive regulation of smooth muscle contraction
GO:0045907 IMP:RGD P positive regulation of vasoconstriction
GO:0042493 IEP:RGD P response to drug
GO:0032496 IEA:Ensembl P response to lipopolysaccharide
GO:0007584 IEP:RGD P response to nutrient
GO:0019932 IEA:Ensembl P second-messenger-mediated signaling
GO:0030104 TAS:RGD P water homeostasis

KEGG Pathway Links

KEGG Pathway ID Description
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction
rno04611 Platelet activation

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5954202 Eicosanoid ligand-binding receptors
5953641 G alpha (12/13) signalling events
5953653 G alpha (q) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5953645 Hemostasis
5953644 Platelet activation, signaling and aggregation
5954201 Prostanoid ligand receptors
5953381 Signal Transduction
5954205 Signal amplification
5953391 Signaling by GPCR
5954204 Thromboxane signalling through TP receptor

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR008365 Prostanoid receptor
IPR001105 Thromboxane receptor

UniProt Annotations

Entry Information

Gene Name
thromboxane A2 receptor
Protein Entry
TA2R_RAT
UniProt ID
P34978
Species
Rat

Comments

Comment Type Description
Function Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.
Similarity Belongs to the G-protein coupled receptor 1 family
Subcellular Location Cell membrane; Multi-pass membrane protein.
Subunit Interacts with RPGRIP1L. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression (By similarity)
Tissue Specificity In the brain, expressed in all types of glial cells. In the kidney, expressed in the mesangial cells of the glomerulus, smooth muscle cells of the renal arterioles, and in transitional cell epithelium of renal pelvis.

Identical and Related Proteins

Unique RefSeq proteins for LMP012440 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8394422 RefSeq NP_058750 341 thromboxane A2 receptor

Identical Sequences to LMP012440 proteins

Reference Database Accession Length Protein Name
GI:8394422 DBBJ BAA06844.1 341 thromboxane A2 receptor [Rattus norvegicus]
GI:8394422 PRF - 341 thromboxane A2 receptor [Rattus norvegicus]

Related Sequences to LMP012440 proteins

Reference Database Accession Length Protein Name
GI:8394422 DBBJ BAA06844.1 341 thromboxane A2 receptor [Rattus norvegicus]
GI:8394422 PRF - 341 thromboxane A2 receptor [Rattus norvegicus]
GI:8394422 SwissProt P34978.1 341 RecName: Full=Thromboxane A2 receptor; Short=TXA2-R; AltName: Full=Prostanoid TP receptor; AltName: Full=TXR2 [Rattus norvegicus]