Gene/Proteome Database (LMPD)

LMPD ID
LMP012474
Gene ID
25126
Species
Rattus norvegicus (Rat)
Gene Name
signal transducer and activator of transcription 5B
Gene Symbol
Stat5b
Alternate Names
signal transducer and activator of transcription 5B; Signal transducer and activator of transcription 5a;
Chromosome
10
Map Location
10q32.1
Summary
member of the STAT family of transcription factors; may mediate biological actions of several interleukins and growth hormones; may be associated with mammary gland development and lactation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Stat5b

Proteins

signal transducer and activator of transcription 5B
Refseq ID NP_071775
Protein GI 11693140
UniProt ID P52632
mRNA ID NM_022380
Length 786
MAMWIQAQQLQGDALHQMQALYGQHFPIEVRHYLSQWIESQAWDSIDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLITQDTESELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFDSQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNSSSNHLEDYNSMSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCEPATAKAADGYVKPQIKQVVPEFVNASADAGSGATYMDQAPSPVVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS

Gene Information

Entrez Gene ID
25126
Gene Name
signal transducer and activator of transcription 5B
Gene Symbol
Stat5b
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0005829 IDA:RGD C cytosol
GO:0005634 IDA:RGD C nucleus
GO:0003677 IDA:RGD F DNA binding
GO:0000979 IEA:Ensembl F RNA polymerase II core promoter sequence-specific DNA binding
GO:0005509 IEA:InterPro F calcium ion binding
GO:0003682 IDA:UniProtKB F chromatin binding
GO:0003690 IDA:RGD F double-stranded DNA binding
GO:0046983 ISS:UniProtKB F protein dimerization activity
GO:0043565 IDA:RGD F sequence-specific DNA binding
GO:0003700 IDA:RGD F sequence-specific DNA binding transcription factor activity
GO:0004871 IEA:Ensembl F signal transducer activity
GO:0006103 IEA:Ensembl P 2-oxoglutarate metabolic process
GO:0007259 IDA:RGD P JAK-STAT cascade
GO:0060397 IEA:Ensembl P JAK-STAT cascade involved in growth hormone signaling pathway
GO:0048541 IEA:Ensembl P Peyer's patch development
GO:0033077 IEA:Ensembl P T cell differentiation in thymus
GO:0043029 IEA:Ensembl P T cell homeostasis
GO:0006953 IDA:RGD P acute-phase response
GO:0000255 IEA:Ensembl P allantoin metabolic process
GO:0071364 IDA:UniProtKB P cellular response to epidermal growth factor stimulus
GO:0071363 ISS:UniProtKB P cellular response to growth factor stimulus
GO:0006101 IEA:Ensembl P citrate metabolic process
GO:0006600 IEA:Ensembl P creatine metabolic process
GO:0046449 IEA:Ensembl P creatinine metabolic process
GO:0046543 IEA:Ensembl P development of secondary female sexual characteristics
GO:0046544 IEA:Ensembl P development of secondary male sexual characteristics
GO:0006631 IEA:Ensembl P fatty acid metabolic process
GO:0007565 IEA:Ensembl P female pregnancy
GO:0006549 IEA:Ensembl P isoleucine metabolic process
GO:0007595 IEA:Ensembl P lactation
GO:0019915 IEA:Ensembl P lipid storage
GO:0001889 IDA:RGD P liver development
GO:0001553 IDA:RGD P luteinization
GO:0001779 IEA:Ensembl P natural killer cell differentiation
GO:0043066 IEA:Ensembl P negative regulation of apoptotic process
GO:0045647 IEA:Ensembl P negative regulation of erythrocyte differentiation
GO:0006107 IEA:Ensembl P oxaloacetate metabolic process
GO:0045579 IEA:Ensembl P positive regulation of B cell differentiation
GO:0042104 IEA:Ensembl P positive regulation of activated T cell proliferation
GO:0051272 IMP:RGD P positive regulation of cellular component movement
GO:0045588 IEA:Ensembl P positive regulation of gamma-delta T cell differentiation
GO:0050729 IEA:Ensembl P positive regulation of inflammatory response
GO:0045086 IEA:Ensembl P positive regulation of interleukin-2 biosynthetic process
GO:0045931 IEA:Ensembl P positive regulation of mitotic cell cycle
GO:0040018 IEA:Ensembl P positive regulation of multicellular organism growth
GO:0032825 IEA:Ensembl P positive regulation of natural killer cell differentiation
GO:0045954 IEA:Ensembl P positive regulation of natural killer cell mediated cytotoxicity
GO:0032819 IEA:Ensembl P positive regulation of natural killer cell proliferation
GO:0048661 IMP:RGD P positive regulation of smooth muscle cell proliferation
GO:0045944 ISS:UniProtKB P positive regulation of transcription from RNA polymerase II promoter
GO:0042448 IEA:Ensembl P progesterone metabolic process
GO:0038161 ISS:UniProtKB P prolactin signaling pathway
GO:0030155 IEA:Ensembl P regulation of cell adhesion
GO:0030856 IEA:Ensembl P regulation of epithelial cell differentiation
GO:0019218 IEA:Ensembl P regulation of steroid metabolic process
GO:0006355 IDA:RGD P regulation of transcription, DNA-templated
GO:0032355 IEA:Ensembl P response to estradiol
GO:0045471 IEP:RGD P response to ethanol
GO:0001666 IEP:RGD P response to hypoxia
GO:0070672 IEA:Ensembl P response to interleukin-15
GO:0070669 IEA:Ensembl P response to interleukin-2
GO:0070670 IEA:Ensembl P response to interleukin-4
GO:0032496 IDA:RGD P response to lipopolysaccharide
GO:0043434 IDA:RGD P response to peptide hormone
GO:0006105 IEA:Ensembl P succinate metabolic process
GO:0019530 IEA:Ensembl P taurine metabolic process
GO:0006366 IDA:RGD P transcription from RNA polymerase II promoter
GO:0006573 IEA:Ensembl P valine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko05221 Acute myeloid leukemia
rno05221 Acute myeloid leukemia
ko04062 Chemokine signaling pathway
rno04062 Chemokine signaling pathway
ko05220 Chronic myeloid leukemia
rno05220 Chronic myeloid leukemia
ko04012 ErbB signaling pathway
rno04012 ErbB signaling pathway
ko05166 HTLV-I infection
rno05166 HTLV-I infection
rno05161 Hepatitis B
ko04630 Jak-STAT signaling pathway
rno04630 Jak-STAT signaling pathway
ko05162 Measles
rno05162 Measles
rno05200 Pathways in cancer
ko04917 Prolactin signaling pathway
rno04917 Prolactin signaling pathway
ko05203 Viral carcinogenesis
rno05203 Viral carcinogenesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953536 Cytokine Signaling in Immune system
5953253 Disease
5953396 Downstream signal transduction
5954321 Growth hormone receptor signaling
5953410 Immune System
5953534 Interleukin-2 signaling
5954001 Interleukin-3, 5 and GM-CSF signaling
5954308 Interleukin-7 signaling
5954400 Nuclear signaling by ERBB4
5954399 Prolactin receptor signaling
5953381 Signal Transduction
5953540 Signaling by ERBB4
5953401 Signaling by FGFR in disease
5954512 Signaling by FGFR mutants
5954510 Signaling by FGFR1 fusion mutants
5954511 Signaling by FGFR1 mutants
5953535 Signaling by Interleukins
5953543 Signaling by Leptin
5953397 Signaling by PDGF
5953541 Signaling by SCF-KIT

Domain Information

InterPro Annotations

Accession Description
IPR011992 EF-hand domain pair
IPR000980 SH2 domain
IPR013801 STAT transcription factor, DNA-binding
IPR012345 STAT transcription factor, DNA-binding, subdomain
IPR013800 STAT transcription factor, all-alpha
IPR015988 STAT transcription factor, coiled coil
IPR013799 STAT transcription factor, protein interaction
IPR001217 Transcription factor STAT
IPR008967 p53-like transcription factor, DNA-binding

UniProt Annotations

Entry Information

Gene Name
signal transducer and activator of transcription 5B
Protein Entry
STA5B_RAT
UniProt ID
P52632
Species
Rat

Comments

Comment Type Description
Function Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription (By similarity)
Ptm Tyrosine phosphorylated. Tyrosine phosphorylated in response to signaling via activated FLT3 and KIT, resulting in translocation to the nucleus. Alternatively, can be phosphorylated by JAK2 (By similarity). Phosphoryation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway (By similarity)
Similarity Belongs to the transcription factor STAT family
Similarity Contains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subcellular Location Cytoplasm . Nucleus . Note=Translocated into the nucleus in response to phosphorylation
Subunit Forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1 and SOCS7 (By similarity). Interacts (via SH2 domain) with INSR

Identical and Related Proteins

Unique RefSeq proteins for LMP012474 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
11693140 RefSeq NP_071775 786 signal transducer and activator of transcription 5B

Identical Sequences to LMP012474 proteins

Reference Database Accession Length Protein Name
GI:11693140 EMBL CAA66141.1 786 stat5b [Rattus norvegicus]
GI:11693140 GenBank EDM06066.1 786 rCG34857 [Rattus norvegicus]

Related Sequences to LMP012474 proteins

Reference Database Accession Length Protein Name
GI:11693140 EMBL CAA66141.1 786 stat5b [Rattus norvegicus]
GI:11693140 GenBank EDM06066.1 786 rCG34857 [Rattus norvegicus]
GI:11693140 SwissProt P52632.1 786 RecName: Full=Signal transducer and activator of transcription 5B [Rattus norvegicus]