Gene/Proteome Database (LMPD)

LMPD ID
LMP012537
Gene ID
25629
Species
Rattus norvegicus (Rat)
Gene Name
perilipin 1
Gene Symbol
Plin1
Synonyms
Plin; PERIA;
Alternate Names
perilipin-1; PERI; lipid droplet-associated protein;
Chromosome
1
Map Location
1q31
Summary
may play a role in lipid metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Plin1

Proteins

perilipin-1
Refseq ID NP_037226
Protein GI 6981372
UniProt ID P43884
mRNA ID NM_013094
Length 517
MSMNKGPTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYNSTKEAHPLVASVCNAYEKGVQGASNLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKGTISTRLRSARNSISVPIASTSDKVLGATLAGCELALGMAKETAEYAANTRVGRLASGGADLALGSIEKVVEYLLPPDKVESAPSSGRQKTQKAPKAKPSLLRRVSTLANTLSRHTMQTTARALKRGHSLAMWIPGVAPLSSLAQWGASAAMQVVSRRQSEVRVPWLHNLAASKDENHEDQTDTEGEETDEEEEEEESEAEENVLREVTALPTPLGFLGGVVHTVQKTLQNTISAVTWAPAAVLGTVGRILHLTPAQAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFQDIDNPPAEVERKGSGSRPASPESTARPGQPRAACAVRGLSAPSCPDLDDKTETSARPGLLAMPREKPARRVSDSFFRPSVMEPILGRTQYSQLRKKS

Gene Information

Entrez Gene ID
25629
Gene Name
perilipin 1
Gene Symbol
Plin1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005811 IDA:RGD C lipid particle
GO:0006629 IEA:UniProtKB-KW P lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR004279 Perilipin

UniProt Annotations

Entry Information

Gene Name
perilipin 1
Protein Entry
PLIN1_RAT
UniProt ID
P43884
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=A; Synonyms=PERIA; IsoId=P43884-1; Sequence=Displayed; Name=B; Synonyms=PERIB; IsoId=P43884-2; Sequence=VSP_004662, VSP_004663;
Function Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone- sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels (By similarity)
Ptm Major cAMP-dependent protein kinase substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL. When unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet
Ptm The N-terminus is blocked.
Similarity Belongs to the perilipin family
Subcellular Location Endoplasmic reticulum . Lipid droplet. Note=Lipid droplet surface-associated.
Subunit Interacts with ABHD5. Interacts with CIDEC (By similarity)
Tissue Specificity Adipocytes.
Web Resource Name=Protein Spotlight; Note=Fat, wonderful fat - Issue 10 of May 2001; URL="http://web.expasy.org/spotlight/back_issues/010";

Identical and Related Proteins

Unique RefSeq proteins for LMP012537 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981372 RefSeq NP_037226 517 perilipin-1

Identical Sequences to LMP012537 proteins

Reference Database Accession Length Protein Name
GI:6981372 GenBank AAB44732.1 517 Sequence 2 from patent US 5585462
GI:6981372 GenBank AAE43154.1 517 Sequence 2 from patent US 6074842
GI:6981372 pat US 517 Sequence 4 from patent US 5739009
GI:6981372 SwissProt P43884.1 517 RecName: Full=Perilipin-1; AltName: Full=Lipid droplet-associated protein [Rattus norvegicus]

Related Sequences to LMP012537 proteins

Reference Database Accession Length Protein Name
GI:6981372 GenBank AAA41830.1 517 perilipin A [Rattus norvegicus]
GI:6981372 GenBank AAB44732.1 517 Sequence 2 from patent US 5585462
GI:6981372 SwissProt P43884.1 517 RecName: Full=Perilipin-1; AltName: Full=Lipid droplet-associated protein [Rattus norvegicus]