Gene/Proteome Database (LMPD)

LMPD ID
LMP012609
Gene ID
29563
Species
Rattus norvegicus (Rat)
Gene Name
cellular retinoic acid binding protein 2
Gene Symbol
Crabp2
Alternate Names
cellular retinoic acid-binding protein 2; CRABP-II; cellular lipid-binding protein; cellular retinoic acid binding protein II; cellular retinoic acid-binding protein II;
Chromosome
2
Map Location
2q34
Summary
may act as an intracellular lipid carrier protein [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Crabp2

Proteins

cellular retinoic acid-binding protein 2
Refseq ID NP_058940
Protein GI 25453404
UniProt ID P51673
mRNA ID NM_017244
Length 139
MPNFSGNWKIIRSENFEEMLKALGVNMMMRKIAVAAASKPAVEIKQENDDTFYIKTSTTVRTTEINFKIGEEFEEQTVDGRPCKSLVKWESENKMVCEQRLLKGEGPKTSWSRELTNDGELILTMTADDVVCTRVYVRE

Gene Information

Entrez Gene ID
29563
Gene Name
cellular retinoic acid binding protein 2
Gene Symbol
Crabp2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:RGD C cytoplasm
GO:0005829 IDA:RGD C cytosol
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0008289 TAS:RGD F lipid binding
GO:0016918 IEA:UniProtKB-KW F retinal binding
GO:0001972 IDA:RGD F retinoic acid binding
GO:0019841 IEA:UniProtKB-KW F retinol binding
GO:0005215 IEA:InterPro F transporter activity
GO:0035115 IEA:Ensembl P embryonic forelimb morphogenesis
GO:0006869 NAS:RGD P lipid transport
GO:0002138 IEP:RGD P retinoic acid biosynthetic process
GO:0042573 NAS:RGD P retinoic acid metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953467 Import of palmitoyl-CoA into the mitochondrial matrix
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953268 Pyruvate metabolism
5953269 Pyruvate metabolism and Citric Acid (TCA) cycle
5954047 Regulation of pyruvate dehydrogenase (PDH) complex
5953270 The citric acid (TCA) cycle and respiratory electron transport

Domain Information

InterPro Annotations

Accession Description
IPR012674 Calycin
IPR011038 Calycin-like
IPR000463 Cytosolic fatty-acid binding
IPR000566 Lipocalin/cytosolic fatty-acid binding domain

UniProt Annotations

Entry Information

Gene Name
cellular retinoic acid binding protein 2
Protein Entry
RABP2_RAT
UniProt ID
P51673
Species
Rat

Comments

Comment Type Description
Domain Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior
Function Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors (By similarity)
Ptm Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.
Similarity Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family
Subcellular Location Cytoplasm. Endoplasmic reticulum {ECO:0000250}. Nucleus . Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus
Subunit Interacts with importin alpha, RXR and RARA

Identical and Related Proteins

Unique RefSeq proteins for LMP012609 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25453404 RefSeq NP_058940 139 cellular retinoic acid-binding protein 2

Identical Sequences to LMP012609 proteins

Reference Database Accession Length Protein Name
GI:25453404 GenBank AAA80225.1 139 cellular retinoic acid-binding protein II [Rattus norvegicus]
GI:25453404 RefSeq XP_003749365.1 139 PREDICTED: cellular retinoic acid-binding protein 2 isoform X2 [Rattus norvegicus]
GI:25453404 SwissProt P51673.2 139 RecName: Full=Cellular retinoic acid-binding protein 2; AltName: Full=Cellular retinoic acid-binding protein II; Short=CRABP-II [Rattus norvegicus]

Related Sequences to LMP012609 proteins

Reference Database Accession Length Protein Name
GI:25453404 GenBank AAA80225.1 139 cellular retinoic acid-binding protein II [Rattus norvegicus]
GI:25453404 RefSeq XP_003749365.1 139 PREDICTED: cellular retinoic acid-binding protein 2 isoform X2 [Rattus norvegicus]
GI:25453404 SwissProt P51673.2 139 RecName: Full=Cellular retinoic acid-binding protein 2; AltName: Full=Cellular retinoic acid-binding protein II; Short=CRABP-II [Rattus norvegicus]