Gene/Proteome Database (LMPD)

LMPD ID
LMP012904
Gene ID
140547
Species
Rattus norvegicus (Rat)
Gene Name
enoyl CoA hydratase, short chain, 1, mitochondrial
Gene Symbol
Echs1
Alternate Names
enoyl-CoA hydratase, mitochondrial; SCEH; enoyl-CoA hydratase 1; short chain enoyl-CoA hydratase; short-chain enoyl-CoA hydratase; enoyl Coenzyme A hydratase, short chain 1; Enoyl-CoA hydratase short chain 1 mitochondrial; Enoyl-CoA hydratase, short chain 1, mitochondrial; mitochondrial short-chain enoyl-coenzyme A hydratase 1; enoyl Coenzyme A hydratase, short chain, 1, mitochondrial;
Chromosome
1
Map Location
1q41
EC Number
4.2.1.17
Summary
catalyzes the conversion of (3S)-3-hydroxyacyl-CoA to trans-2(or 3)-enoyl-CoA and H2O in fatty acid beta-oxidation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Echs1

Proteins

enoyl-CoA hydratase, mitochondrial precursor
Refseq ID NP_511178
Protein GI 17530977
UniProt ID P14604
mRNA ID NM_078623
Length 290
MAALRALLPRACNSLLSPVRCPEFRRFASGANFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEEDPAVGAIVLTGGEKAFAAGADIKEMQNRTFQDCYSGKFLSHWDHITRIKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVETLVEEAIQCAEKIANNSKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYSTFATDDRREGMSAFVEKRKANFKDH
transit_peptide: 1..29 experiment: experimental evidence, no additional details recorded note: Mitochondrion; propagated from UniProtKB/Swiss-Prot (P14604.1) calculated_mol_wt: 3247 peptide sequence: MAALRALLPRACNSLLSPVRCPEFRRFAS mat_peptide: 30..290 product: Enoyl-CoA hydratase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P14604.1) calculated_mol_wt: 28288 peptide sequence: GANFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEEDPAVGAIVLTGGEKAFAAGADIKEMQNRTFQDCYSGKFLSHWDHITRIKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVETLVEEAIQCAEKIANNSKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYSTFATDDRREGMSAFVEKRKANFKDH

Gene Information

Entrez Gene ID
140547
Gene Name
enoyl CoA hydratase, short chain, 1, mitochondrial
Gene Symbol
Echs1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:RGD C mitochondrion
GO:0004300 IDA:RGD F enoyl-CoA hydratase activity
GO:0006635 IMP:RGD P fatty acid beta-oxidation

KEGG Pathway Links

KEGG Pathway ID Description
ko00650 Butanoate metabolism
rno00650 Butanoate metabolism
ko01200 Carbon metabolism
rno01200 Carbon metabolism
M00085 Fatty acid biosynthesis, elongation, mitochondria
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko00062 Fatty acid elongation
rno00062 Fatty acid elongation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
ko00310 Lysine degradation
rno00310 Lysine degradation
M00032 Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00013 Malonate semialdehyde pathway, propanoyl-CoA => Acetyl-CoA
rno01100 Metabolic pathways
ko00640 Propanoate metabolism
rno00640 Propanoate metabolism
ko00380 Tryptophan metabolism
rno00380 Tryptophan metabolism
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation
ko00410 beta-Alanine metabolism
rno00410 beta-Alanine metabolism
M00087 beta-Oxidation

REACTOME Pathway Links

REACTOME Pathway ID Description
5953500 Beta oxidation of butanoyl-CoA to acetyl-CoA
5953503 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
5953501 Beta oxidation of hexanoyl-CoA to butanoyl-CoA
5953496 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
5953502 Beta oxidation of octanoyl-CoA to hexanoyl-CoA
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953287 Mitochondrial Fatty Acid Beta-Oxidation
5953497 mitochondrial fatty acid beta-oxidation of saturated fatty acids

Domain Information

InterPro Annotations

Accession Description
IPR029045 ClpP/crotonase-like domain
IPR001753 Crotonase_core_superfam
IPR018376 Enoyl-CoA hydratase/isomerase, conserved site

UniProt Annotations

Entry Information

Gene Name
enoyl CoA hydratase, short chain, 1, mitochondrial
Protein Entry
ECHM_RAT
UniProt ID
P14604
Species
Rat

Comments

Comment Type Description
Catalytic Activity (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl- CoA + H(2)O.
Function Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate.
Pathway Lipid metabolism; fatty acid beta-oxidation.
Similarity Belongs to the enoyl-CoA hydratase/isomerase family
Subcellular Location Mitochondrion matrix .
Subunit Homohexamer; dimer of trimers. {ECO:0000269|PubMed:11851409, ECO:0000269|PubMed:12445775, ECO:0000269|PubMed:8895557, ECO:0000269|PubMed:9480773}.
Tissue Specificity Detected in liver (at protein level)

Identical and Related Proteins

Unique RefSeq proteins for LMP012904 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17530977 RefSeq NP_511178 290 enoyl-CoA hydratase, mitochondrial precursor

Identical Sequences to LMP012904 proteins

Reference Database Accession Length Protein Name
GI:17530977 GenBank AEW41523.1 290 Sequence 48 from patent US 8076120
GI:17530977 GenBank AFN90988.1 290 Sequence 48 from patent US 8198066
GI:17530977 GenBank AGV79217.1 290 Sequence 48 from patent US 8501455
GI:17530977 RefSeq XP_003748934.1 290 PREDICTED: enoyl-CoA hydratase, mitochondrial [Rattus norvegicus]

Related Sequences to LMP012904 proteins

Reference Database Accession Length Protein Name
GI:17530977 GenBank ABP13466.1 290 Sequence 48 from patent US 7186541
GI:17530977 GenBank EDM11897.1 290 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial, isoform CRA_a [Rattus norvegicus]
GI:17530977 GenBank ADC21052.1 290 Sequence 48 from patent US 7638316