Gene/Proteome Database (LMPD)

LMPD ID
LMP013088
Gene ID
292156
Species
Rattus norvegicus (Rat)
Gene Name
SH3-domain GRB2-like endophilin B1
Gene Symbol
Sh3glb1
Alternate Names
endophilin-B1; SH3-domain GRB2-like B1 (endophilin); sh3glb1 {ECO:0000312|EMBL:AAH79085.1}; SH3 domain-containing GRB2-like protein B1;
Chromosome
2
Map Location
2q44

Proteins

endophilin-B1
Refseq ID NP_001011929
Protein GI 58865428
UniProt ID Q6AYE2
mRNA ID NM_001011929
Length 365
MNIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKVWTEKIMKQTEVLLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETKSSSEQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYVSNNNQTSGTPVPYTLSNTIGPSAVASTGSLVITCPPNLSDLKDSSSTRKARVLYDYDAANSTELSLLADEVITVFSVVGMDSDWLMGERGNQKGKVPITYLELLN

Gene Information

Entrez Gene ID
292156
Gene Name
SH3-domain GRB2-like endophilin B1
Gene Symbol
Sh3glb1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005741 IEA:UniProtKB-KW C mitochondrial outer membrane
GO:0043234 IEA:Ensembl C protein complex
GO:0005504 IEA:Ensembl F fatty acid binding
GO:0042171 IEA:Ensembl F lysophosphatidic acid acyltransferase activity
GO:0051084 IEA:Ensembl P 'de novo' posttranslational protein folding
GO:0006915 IEA:UniProtKB-KW P apoptotic process
GO:0006654 IEA:Ensembl P phosphatidic acid biosynthetic process
GO:1900740 IEA:Ensembl P positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0032461 IEA:Ensembl P positive regulation of protein oligomerization
GO:0051259 IEA:Ensembl P protein oligomerization

KEGG Pathway Links

KEGG Pathway ID Description
ko04144 Endocytosis
rno04144 Endocytosis

Domain Information

InterPro Annotations

Accession Description
IPR027267 Arfaptin homology (AH) domain/BAR domain
IPR004148 BAR domain
IPR028503 Endophilin-B1
IPR001452 SH3_domain

UniProt Annotations

Entry Information

Gene Name
SH3-domain GRB2-like endophilin B1
Protein Entry
SHLB1_RAT
UniProt ID
Q6AYE2
Species
Rat

Comments

Comment Type Description
Domain An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes
Function May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion (By similarity)
Ptm Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization
Similarity Belongs to the endophilin family
Similarity Contains 1 BAR domain. {ECO:0000255|PROSITE- ProRule:PRU00361}.
Similarity Contains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Subcellular Location Cytoplasm . Golgi apparatus membrane ; Peripheral membrane protein . Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9JK48, ECO:0000250|UniProtKB:Q9Y371}; Peripheral membrane protein . Note=Association with the Golgi apparatus depends on the cell type. {ECO:0000250|UniProtKB:Q9JK48, ECO:0000250|UniProtKB:Q9Y371, ECO:0000269|PubMed:11604418}.
Subunit Homodimer, and heterodimer with SH3GLB2. Binds BAX. Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1 (By similarity)
Tissue Specificity Expressed in brain, heart, lung and spleen. Low level in liver and testis

Identical and Related Proteins

Unique RefSeq proteins for LMP013088 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
58865428 RefSeq NP_001011929 365 endophilin-B1

Identical Sequences to LMP013088 proteins

Reference Database Accession Length Protein Name
GI:58865428 GenBank AAH79085.1 365 SH3-domain GRB2-like endophilin B1 [Rattus norvegicus]
GI:58865428 SwissProt Q6AYE2.1 365 RecName: Full=Endophilin-B1; AltName: Full=SH3 domain-containing GRB2-like protein B1 [Rattus norvegicus]

Related Sequences to LMP013088 proteins

Reference Database Accession Length Protein Name
GI:58865428 GenBank AAH24362.1 365 SH3-domain GRB2-like B1 (endophilin) [Mus musculus]
GI:58865428 GenBank AAH79085.1 365 SH3-domain GRB2-like endophilin B1 [Rattus norvegicus]
GI:58865428 RefSeq XP_006233495.1 386 PREDICTED: endophilin-B1 isoform X2 [Rattus norvegicus]
GI:58865428 SwissProt Q6AYE2.1 365 RecName: Full=Endophilin-B1; AltName: Full=SH3 domain-containing GRB2-like protein B1 [Rattus norvegicus]