Gene/Proteome Database (LMPD)

LMPD ID
LMP013179
Gene ID
299732
Species
Rattus norvegicus (Rat)
Gene Name
leukotriene A4 hydrolase
Gene Symbol
Lta4h
Alternate Names
leukotriene A-4 hydrolase; LTA-4 hydrolase;
Chromosome
7
Map Location
7q13
EC Number
3.3.2.6

Proteins

leukotriene A-4 hydrolase
Refseq ID NP_001025202
Protein GI 71795621
UniProt ID Q499P2
mRNA ID NM_001030031
Length 611
MPEVADTCSLASPASVCRTQHLHLRCSVDFARRALTGTAALTVQSQEDNLRSLTLDTKDLTIEKVVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVEKFSYQSVTTDDWKSFLYAHFKDKVDLLNQVDWNAWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAKEEDLNSFSIEDLKDLSSHQLNEFLAQVLQKAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKACMHPVTAMLVGKDLKVD

Gene Information

Entrez Gene ID
299732
Gene Name
leukotriene A4 hydrolase
Gene Symbol
Lta4h
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-SubCell C cytoplasm
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005634 IEA:Ensembl C nucleus
GO:0004177 IEA:Ensembl F aminopeptidase activity
GO:0004463 IEA:UniProtKB-EC F leukotriene-A4 hydrolase activity
GO:0008237 IEA:UniProtKB-KW F metallopeptidase activity
GO:0044822 IEA:Ensembl F poly(A) RNA binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0019370 IEA:UniProtKB-KW P leukotriene biosynthetic process
GO:0043171 IEA:Ensembl P peptide catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00590 Arachidonic acid metabolism
rno00590 Arachidonic acid metabolism
rno01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5953493 Arachidonic acid metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954082 Synthesis of Leukotrienes (LT) and Eoxins (EX)

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR012777 Leukotriene A4 hydrolase
IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
IPR015211 Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal

UniProt Annotations

Entry Information

Gene Name
leukotriene A4 hydrolase
Protein Entry
Q499P2_RAT
UniProt ID
Q499P2
Species
Rat

Comments

Comment Type Description
Catalytic Activity (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa- 7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12- dihydroxyicosa-6,8,10,14-tetraenoate
Cofactor Note=Binds 1 zinc ion per subunit. ;
Pathway Lipid metabolism; leukotriene B4 biosynthesis
Similarity Belongs to the peptidase M1 family
Subcellular Location Cytoplasm .

Identical and Related Proteins

Unique RefSeq proteins for LMP013179 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
71795621 RefSeq NP_001025202 611 leukotriene A-4 hydrolase

Identical Sequences to LMP013179 proteins

Reference Database Accession Length Protein Name
GI:71795621 GenBank AAH99819.1 611 Leukotriene A4 hydrolase [Rattus norvegicus]

Related Sequences to LMP013179 proteins

Reference Database Accession Length Protein Name
GI:71795621 GenBank AAB21778.1 610 leukotriene A4 hydrolase [Rattus sp.]
GI:71795621 GenBank AAH21417.1 611 Lta4h protein [Mus musculus]
GI:71795621 GenBank AAH99819.1 611 Leukotriene A4 hydrolase [Rattus norvegicus]
GI:71795621 SwissProt P30349.2 610 RecName: Full=Leukotriene A-4 hydrolase; Short=LTA-4 hydrolase; AltName: Full=Leukotriene A(4) hydrolase [Rattus norvegicus]