Gene/Proteome Database (LMPD)

LMPD ID
LMP013414
Gene ID
353317
Species
Rattus norvegicus (Rat)
Gene Name
acyl-CoA synthetase medium-chain family member 4
Gene Symbol
Acsm4
Synonyms
Omacs;
Alternate Names
acyl-coenzyme A synthetase ACSM4, mitochondrial; O-MACS; olfactory specific medium-chain acyl CoA synthetase;
Chromosome
1
Map Location
1q35
EC Number
6.2.1.2
Summary
acyl-CoA synthase enzyme involved in fatty acid metabolism; may be involved in processing odorants [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acsm4

Proteins

acyl-coenzyme A synthetase ACSM4, mitochondrial precursor
Refseq ID NP_859046
Protein GI 32140186
UniProt ID Q7TN78
mRNA ID NM_181695
Length 580
MKVLLRCQRLRFIWLAKPAGRHFHRDPQLWAPLTLDDFEAINRCEKPLPKNFNFAADVLDQWSLKEKSGERPANPALWWVNGKGDEVKWSFQELGSLSRKAANVLTKPCGLQRGDRVAVILPRIPEWWLINVACMRTGLVFMPGTIQLTRKDILYRLQASKAKCIVASEEVAPAVDSIASECPNLKTKLLVSPHRWDGWLSFQELLQSASEEHNCVQTGSQEPMAIYFTSGTTGSPKMAQHSQSSLGIGYALCGRYWLDLTSSDIMWNMSDTGWIKAAIGSVFSTWLRGACVFVHRMAQFNTDTFLDTLTSYPITTLCSAPTVYRMLVQQDLKRYQFKRLRHCLTGGEPLNPEVLEQWKAQTGLELYEGYGQTEVGIICANRKGEEIKPGSMGKGVVPYDVQIIDEHGNILPSGKEGEIALRLGSDRPFCFFSEYVDNPEKTDATIRRNFYITGDRGVMDDDGYLWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDPIRGEVVKAFIVLAAPFKSSNREKLTAELQDHVKNSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWGRA
transit_peptide: 1..22 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q7TN78.1) calculated_mol_wt: 2693 peptide sequence: MKVLLRCQRLRFIWLAKPAGRH mat_peptide: 23..580 product: Acyl-coenzyme A synthetase ACSM4, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q7TN78.1) calculated_mol_wt: 62642 peptide sequence: FHRDPQLWAPLTLDDFEAINRCEKPLPKNFNFAADVLDQWSLKEKSGERPANPALWWVNGKGDEVKWSFQELGSLSRKAANVLTKPCGLQRGDRVAVILPRIPEWWLINVACMRTGLVFMPGTIQLTRKDILYRLQASKAKCIVASEEVAPAVDSIASECPNLKTKLLVSPHRWDGWLSFQELLQSASEEHNCVQTGSQEPMAIYFTSGTTGSPKMAQHSQSSLGIGYALCGRYWLDLTSSDIMWNMSDTGWIKAAIGSVFSTWLRGACVFVHRMAQFNTDTFLDTLTSYPITTLCSAPTVYRMLVQQDLKRYQFKRLRHCLTGGEPLNPEVLEQWKAQTGLELYEGYGQTEVGIICANRKGEEIKPGSMGKGVVPYDVQIIDEHGNILPSGKEGEIALRLGSDRPFCFFSEYVDNPEKTDATIRRNFYITGDRGVMDDDGYLWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDPIRGEVVKAFIVLAAPFKSSNREKLTAELQDHVKNSTAPYKYPRKVEFVQELPKTITGKIKRNVLRDQEWGRA

Gene Information

Entrez Gene ID
353317
Gene Name
acyl-CoA synthetase medium-chain family member 4
Gene Symbol
Acsm4
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:RGD C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0047760 IEA:UniProtKB-EC F butyrate-CoA ligase activity
GO:0004321 IDA:RGD F fatty-acyl-CoA synthase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0005549 NAS:RGD F odorant binding
GO:0006637 IDA:RGD P acyl-CoA metabolic process
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process
GO:0007608 NAS:RGD P sensory perception of smell

KEGG Pathway Links

KEGG Pathway ID Description
ko00650 Butanoate metabolism
rno00650 Butanoate metabolism
rno01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR025110 AMP-binding enzyme C-terminal domain
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase medium-chain family member 4
Protein Entry
ACSM4_RAT
UniProt ID
Q7TN78
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ;
Developmental Stage Detected in all cell layers of the dorso- medial part of the embryonic olfactory placode and olfactory epithelium. First detected in olfactory placode on embryonic day 11.5. Detected in olfactory placode on embryonic day 12, 14, 16 and 18
Function Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro)
Similarity Belongs to the ATP-dependent AMP-binding enzyme family
Subcellular Location Mitochondrion matrix .
Tissue Specificity Detected in adult olfactory epithelium

Identical and Related Proteins

Unique RefSeq proteins for LMP013414 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
32140186 RefSeq NP_859046 580 acyl-coenzyme A synthetase ACSM4, mitochondrial precursor

Identical Sequences to LMP013414 proteins

Reference Database Accession Length Protein Name
GI:32140186 DBBJ BAC77614.1 580 olfactory specific medium-chain acyl CoA synthetase [Rattus norvegicus]
GI:32140186 SwissProt Q7TN78.1 580 RecName: Full=Acyl-coenzyme A synthetase ACSM4, mitochondrial; AltName: Full=Olfactory specific medium-chain acyl CoA synthetase; Short=O-MACS; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013414 proteins

Reference Database Accession Length Protein Name
GI:32140186 DBBJ BAC77614.1 580 olfactory specific medium-chain acyl CoA synthetase [Rattus norvegicus]
GI:32140186 GenBank AAH48390.1 580 Acyl-CoA synthetase medium-chain family member 4 [Mus musculus]
GI:32140186 RefSeq NP_848501.1 580 acyl-coenzyme A synthetase ACSM4, mitochondrial precursor [Mus musculus]
GI:32140186 SwissProt Q7TN78.1 580 RecName: Full=Acyl-coenzyme A synthetase ACSM4, mitochondrial; AltName: Full=Olfactory specific medium-chain acyl CoA synthetase; Short=O-MACS; Flags: Precursor [Rattus norvegicus]