Gene/Proteome Database (LMPD)

LMPD ID
LMP014311
Gene ID
709528
Species
Macaca mulatta (Rhesus monkey)
Gene Name
lipoprotein, Lp(a)
Gene Symbol
LPA
Synonyms
Lp(a); Apo(a);
Alternate Names
lipoprotein, Lp(a); apolipoprotein(a);
Chromosome
4
Map Location
chromosome:4

Proteins

Refseq ID XP_001098061
Protein GI 297292025
mRNA ID XM_001098061
Length 1503
MRTALPVGKLEGGYGWQHLAEGLVMEVNNILGWGHTFWALLASPIMEHKEVVLLLLLFLKSALPEQSHVVQDCYHGDGQSYQGTSSTTVTGRTCQAWSSMEPHQHNRTTENYPNAGLIRNYCRNPDPVAAPYCYTMDPNVRWEYCNLTQCSDAEGTAVAPPNVTLVPSLEAPSEQSPTEQRPGVQECYHGNGQSYRGTYFTTVTGRTCQAWSSMTPHSHSRTPENYPNGGLIRNYCRNPDPVAAPYCYTMDPNVRWEYCNLTQCSDAEGIAVTPLTVTPVPSLEAPSKQAPTEQRPGVQECYHGNGQSYRGTYFTTVTGRTCQAWSSMTPHSHSRTPENYPNGSPTSSDLLVYPAVFLDAMGPTVLSTHPLSLSPGVAATSRGYIESKREAPTEQRPGVQECYHGNGQSYRGTYFTTVTGRTCQAWSSMTPHSHSRTPENYPNGGLIRNYCRNPDPVAAPYCYTMDPSVRWEYCNLTQCSDAEGTAVAPPNVTPVPSLEAPSEQAPTEQRLGVQECYHSNGQSYRGTYFTTVTGRTCQAWSSMTPHSHSRTPENYPNAGLVKNYCRNPDPVAAPWCYTTDPSVRWEYCNLTRCSDAEGTAVVPPNIIPVPSLEAFLEQEPTEETPGVQECYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSRTPKNYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCLVTESSVLETLTVVPDPSTQASSEEAPTEQSPEVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPDGGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVTESSVLATSMAVSEQAPMEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTIEYYPNGGLTKNYCRNPDAEIRPWCYTMDPRVRWEYCNLTQCVVMESSVLATPMVVPVPSREVPSEEAPTENSPGVQDCYQGDGQSYRGTFSTTITGRTCQSWLSMTPHRHRRIPLRYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVTESSVLTTPTVVPVPSTEAPSEQAPPEKSPVVQDCYHGDGQSYRGTSSTTVTGRNCQSWSSMIPHWHQRTPENYPNAGLTRNYCRNPDSGKQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPTEQTPVVQQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHQHKRTPENHPNDGLTMNYCRNPDADTGPWCFTMDPSVRREYCNLTRCSDTEGTVVTPPTVIPVPSLEAPSEQASSSFDCGKPQVEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAACCLETFSRPSFYKVILGAHQEVNLESHVQEIEVSRLFLEPIGADIALLKLSRPAIITDKVIPACLPSPNYVITAWTECYITGWGETQGEIKSIAHGDNGGPVVCFDKDKYILRGITSWGPGCACPNKPGVYVRVSSFVTWIEGVMRNN

Gene Information

Entrez Gene ID
709528
Gene Name
lipoprotein, Lp(a)
Gene Symbol
LPA
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0004252 IEA:InterPro F serine-type endopeptidase activity
GO:0006869 IEA:UniProtKB-KW P lipid transport

Domain Information

InterPro Annotations

Accession Description
IPR000001 Kringle
IPR018056 Kringle, conserved site
IPR013806 Kringle-like fold
IPR001254 Peptidase_S1
IPR001314 Peptidase_S1A
IPR009003 Trypsin-like cysteine/serine peptidase domain

UniProt Annotations

Entry Information

Gene Name
lipoprotein, Lp(a)
Species
Rhesus monkey

Comments

Comment Type Description
Disease Note=Elevated plasma concentrations of apo(a) and its naturally occurring proteolytic fragments are correlated with atherosclerosis. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin(ogen) binding.
Function Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.
Miscellaneous Apo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-Lp(a). Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation (By similarity). {ECO:0000250}.
Ptm N- and O-glycosylated. {ECO:0000250}.
Similarity Belongs to the peptidase S1 family. Plasminogen subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
Similarity Contains 1 peptidase S1 domain. {ECO:0000255|PROSITE- ProRule:PRU00274}.
Similarity Contains at least 10 kringle domains. {ECO:0000305}.
Subunit Disulfide-linked to apo-B100. Binds to fibronectin and decorin (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP014311 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
297292025 RefSeq XP_001098061 1503

Identical Sequences to LMP014311 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP014311 proteins

Reference Database Accession Length Protein Name
GI:297292025 GenBank AAA36833.1 1420 apolipoprotein(a), partial [Macaca mulatta]
GI:297292025 RefSeq XP_005551556.1 1543 PREDICTED: apolipoprotein(a) [Macaca fascicularis]
GI:297292025 RefSeq XP_008006112.1 2116 PREDICTED: apolipoprotein(a) [Chlorocebus sabaeus]
GI:297292025 SwissProt P14417.1 1420 RecName: Full=Apolipoprotein(a); Short=Apo(a); Short=Lp(a), partial [Macaca mulatta]