LIPID MAPS

Structure Database (LMSD)

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Common Name

Hispidulin

Systematic Name

Synonyms

LM ID

LMPK12111159

Formula

C₁₆H₁₂O₆

Exact Mass

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300.06339

Status

Curated

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Classification

Biological Context

Hispidulin is a flavonoid originally isolated from A. montana with diverse biological activities.^1,2,3,4,5 It inhibits platelet aggregation induced by platelet-activating factor (PAF), arachidonic acid , and ADP (IC50s = 20, 4, and 13 μM, respectively).¹ Hispidulin inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 cells and bone marrow-derived macrophages (BMMs).² In vivo, hispidulin (25 μg/kg) inhibits LPS-induced bone resorption in mice. It inhibits sphingosine kinase 1 (SPHK1) and induces ceramide accumulation and apoptosis in Caki-2 renal carcinoma cells in vitro and inhibits tumor growth in a Caki-2 mouse xenograft model.³ Pretreatment with hispidulin (40 mg/kg) reduces cognitive deficits in the Morris water maze induced by sevoflurane in aged rats.⁴ It also decreases infarct size and brain edema in a rat model of focal cerebral ischemia and reperfusion injury.⁵

This information has been provided by Cayman Chemical

References

1. Bourdillat, B., Delautier, D., Labat, C., et al. Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. Eur. J. Pharmacol. 147(1), 1-6 (1988).

2. Nepal, M., Choi, H.J., Choi, B.-Y., et al. Hispidulin attenuates bone resorption and osteoclastogenesis via the RANKL-induced NF-κB and NFATc1 pathways. Eur. J. Pharmacol. 715(1-3), 96-104 (2013).

3. Gao, H., Gao, M.-Q., Peng, J.-J., et al. Hispidulin mediates apoptosis in human renal cell carcinoma by inducing ceramide accumulation. Acta Pharmacol. Sin. 38(12), 1618-1631 (2017).

4. Huang, L., Huang, K., and Ning, H. Autophagy induction by hispidulin provides protection against sevoflurane-induced neuronal apoptosis in aged rats. Biomed. Pharmacother. 98, 460-468 (2018).

5. An, P., Wu, T., Yu, H., et al. Hispidulin protects against focal cerebral ischemia reperfusion injury in rats. J. Mol. Neurosci. 65(2), 203-212 (2018).