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Structure Database (LMSD)

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Common Name

Cirsimaritin

Systematic Name

Synonyms

LM ID

LMPK12111163

Formula

C₁₇H₁₄O₆

Exact Mass

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314.07904

Status

Curated

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Classification

Biological Context

Cirsimaritin is a flavone that has been found in D. kotschyi and has diverse biological activities.^1,2,3,4,5 It binds to rat adenosine A1, rat A2A, and human A3 receptors (Kis = 1.2, 3, and 1.72 µM, respectively, in radioligand binding assays), as well as inhibits dipeptidyl peptidase 4 (DPP-4; IC50 = 0.43 µM).^1,2 Cirsimaritin is active against the chloroquine-sensitive NF54 strain of P. falciparum (IC50 = 16.9 µM).³ It inhibits the proliferation of AGS, HT-29, Saos-2, and WEHI 164 cells (IC50s = 14.4, 13.1, 38.5, and 40.7 µM, respectively).⁴ Cirsimaritin (10 mg/kg) increases the number of entries into, and percentage of time spent in, the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.⁵

This information has been provided by Cayman Chemical

References

1. Abdelhalim, A., Karim, N., Chebib, M., et al. Antidepressant, anxiolytic and antinociceptive activities of constituents from Rosmarinus officinalis. J. Pharm. Pharm. Sci. 18(4), 448-459 (2015).

2. Moghaddam, G., Ebrahimi, S.A., Rahbar-Roshandel, N., et al. Antiproliferative activity of flavonoids: Influence of the sequential methoxylation state of the flavonoid structure. Phytother. Res. 26(7), 1023-1028 (2012).

3. Tasdemir, D., Lack, G., Brun, R., et al. Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J. Med. Chem. 49(11), 3345-3353 (2006).

4. Li, N., Wang, L.-J., Jiang, B., et al. Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus. Eur. J. Med. Chem. 151, 145-157 (2018).

5. Ji, X.-d., Melman, N., and Jacobson, K.A. Interactions of flavonoids and other phytochemicals with adenosine receptors. J. Med. Chem. 39(3), 781-788 (1996).