Eupafolin is a flavonoid that has been found in E. adenophorum and has diverse biological activities.^1,2,3,4 It inhibits iron-dependent lipid peroxidation in a cell-free assay (IC50 = 7.9 µM).¹ Eupafolin (50-150 µM) inhibits prion protein 106-126 (PrP106-126) aggregation in a cell-free assay and reduces PrP106-126-induced cell death in SH-SY5Y cells.² It inhibits the production of hemolysin and leukocidin by methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) and reduces S. aureus-induced hemolysis of erythrocytes in isolated rabbit whole blood when used at a concentration of 100 µM.³ In vivo, eupafolin (100 mg/kg) reduces the number of lung colony-forming units (CFUs) and increases survival in a mouse model of MRSA infection. It also reduces angiogenesis and tumor volume in a Hep3B hepatocellular carcinoma (HCC) mouse xenograft model when administered at a dose of 60 mg/kg.⁴