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Structure Database (LMSD)

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Common Name

Ombuin

Systematic Name

3,5,3'-Trihydroxy-7,4'-dimethoxyflavone

Synonyms

4',7-Dimethylquercetin

LM ID

LMPK12112652

Formula

C₁₇H₁₄O₇

Exact Mass

Calculate m/z

330.073955

Status

Curated

Show lipids differing only in stereochemistry/bond geometry

Classification

Biological Context

Ombuin is a flavonoid that has been found in B. balsamifera and has diverse biological activities.^1,2,3,4 It is an antagonist of M1 muscarinic acetylcholine receptors (mAChRs; Ki = 42 µM in CHO-K1 cells expressing the human receptor).² Ombuin is cytotoxic to HepG2 hepatocellular carcinoma cells (IC50 = 1.5 µg/ml).³ In vivo, ombuin (40 mg/kg per day) reduces blood urea and glucose levels, urinary volume and protein levels, serum creatinine levels, renal fibrosis levels, and body weight in a rat model of diabetic nephropathy induced by streptozotocin (STZ; Item No. 13104).⁴

This information has been provided by Cayman Chemical

References

1. Nessa, F., Ismail, Z., Mohamed, N., et al. Free radical-scavenging activity of organic extracts and of pure flavonoids of Blumea balsamifera DC leaves. Food Chem. 88(2), 243-252 (2004).

2. Swaminathan, M., Chee, C.F., Chin, S.P., et al. Flavonoids with M1 muscarinic acetylcholine receptor binding activity. Molecules 19(7), 8933-8948 (2014).

3. Huong, D.T., Luong, D.V., Thao, T.T.P., et al. A new flavone and cytotoxic activity of flavonoid constituents isolated from Miliusa balansae (Annonaceae). Pharmazie 60(8), 627-629 (2005).

4. Liu, B., Deng, C., and Tan, P. Ombuin ameliorates diabetic nephropathy in rats by anti-inflammation and antifibrosis involving Notch 1 and PPAR γ signaling pathways. Drug Dev. Res. 83(6), 1270-1280 (2022).